Induction of Donor-Specific Tolerance: Is This Achievable?
نویسندگان
چکیده
منابع مشابه
Induction of Donor-Specific Tolerance: Is This Achievable?
To the Editor, The final goal of transplant physicians is the induction of donor-specific tolerance (DST), in which the host permanently accepts the graft, but immunity against other antigens is maintained. There have been reports of successful induction of DST in rodent models. However, the majority of studies have focused primarily on the inhibition of costimulatory signals that regulate the ...
متن کاملProduction of donor T cells is critical for induction of donor-specific tolerance and maintenance of chimerism.
Nonmyeloablative conditioning has significantly reduced the morbidity associated with bone marrow transplantation. The donor hemopoietic cell lineage(s) responsible for the induction and maintenance of tolerance in nonmyeloablatively conditioned recipients is not defined. In the present studies we evaluated which hemopoietic stem cell-derived components are critical to the induction of toleranc...
متن کاملCorrelation between Lymphocyte - induced Donor - specific Tolerance and Donor Cell
Intravenous infusion of mice with major histocompatibility complex (MHC) incompatible lymphocytes can inhibit the response of recipient T cells capable of recognizing the injected cells, and can enhance survival of grafts sharing MHC with the injected cells. However, neither T cell inactivation nor graft survival enhancement is always achieved. This is particularly true for donor cells that are...
متن کاملMechanisms of donor-specific transfusion tolerance: preemptive induction of clonal T-cell exhaustion via indirect presentation.
Induction of transplantation tolerance to alloantigens without general immunosuppression remains an enduring challenge. Injecting a donor-specific transfusion (DST) of spleen cells together with blocking alphaCD154 antibody prior to graft transplantation is an effective way to induce long-lived graft acceptance. Using a novel T-cell receptor (TCR) transgenic (Tg) model of CD4+ T-cell-mediated r...
متن کاملIn utero hematopoietic cell transplantation: induction of donor specific immune tolerance and postnatal transplants
In utero hematopoietic cell transplantation (IUHCT) is a non-myeloablative non-immunosuppressive transplant approach that allows for donor cell engraftment across immunologic barriers. Successful engraftment is associated with donor-specific tolerance. IUHCT has the potential to treat a large number of congenital hematologic, immunologic, and genetic diseases either by achieving high enough eng...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: The Korean Journal of Internal Medicine
سال: 2012
ISSN: 1226-3303,2005-6648
DOI: 10.3904/kjim.2012.27.1.114